Molecular subtyping of hypertensive disorders of pregnancy

Molecular subtyping of hypertensive disorders of pregnancy

Blog Article

Abstract Hypertensive disorders of pregnancy (HDP), including preeclampsia, affect 1 in 6 pregnancies, are major contributors to maternal morbidity and mortality, yet lack precision medicine strategies.Analyzing transcriptomic data from a prospectively-collected Equipment diverse cohort (n = 9102), this study reveals distinct RNA subtypes in maternal blood, reclassifying clinical HDP phenotypes like early/late-onset preeclampsia.The placental gene PAPPA2 strongly predicts the most severe forms of preeclampsia in individuals without pre-existing high risk factors, months before symptoms, and its overexpression correlates with earlier delivery in a dose-dependent manner.

Further, molecular subtypes Main Board Wire Harness characterized by immune genes are upregulated in less severe forms of HDP.These results reclassify HDP clinical phenotypes into two distinct molecular subtypes, placental-associated or immune-associated.Validation performance for placental-associated HDP yields an AUC of 0.

88 in the advanced maternal age population without pre-existing high risk factors.Molecular subtypes create new opportunities to apply precision-based medicine in maternal health.